The 10th Shanghai International Conference on Radiation Oncology (SICRO) was held in Shanghai, from 10th to 11st August 2018. During the conference, Prof. Stephen M. Hahn, MD Anderson’s Chief Medical Executive, delivered an enlightening speech entitled “The Role of Radiation Oncology in Precision Oncology”. Seizing this opportunity, the Editorial Office of Precision Cancer Medicine had the great honor to invite Prof. Stephen M. Hahn for an interview, sharing with us his opinions about the future and challenge of radiation therapy in precision oncology as well as his special experience in serving MD Anderson.