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4-1BB-mediated cancer immunotherapy: ‘mission impossible’ for non-engineered IgGs?

   
@article{PCM4665,
	author = {Luis Alvarez-Vallina},
	title = {4-1BB-mediated cancer immunotherapy: ‘mission impossible’ for non-engineered IgGs?},
	journal = {Precision Cancer Medicine},
	volume = {2},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Increasing tumor-specific immune responses with immunostimulatory monoclonal antibodies (mAbs) is a promising strategy in cancer therapy. Antagonistic mAbs blocking signaling through inhibitory receptors such as cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death-1 (PD-1) have been shown to induce sustained anti-tumor responses in many cancers across various histologies, and agonistic mAbs targeting activator receptors are undergoing clinical trials (1).},
	issn = {2617-2216},	url = {https://pcm.amegroups.org/article/view/4665}
}